List of Projects

Here is a list of main projects carried our in various centers run by Dr Ghaffari since 2001
2018-present Collaborative Project: Hope Generation Foundation Ministry of Health and Medical Education   Targeted next generation sequencing of known genes associated with mucopolysaccharidosis in 320 patients registered in Iran Food and Drug Organization
2018-present Collaborative Project: Hope Generation Foundation Vali E-Asr Rehabilitation Foundation   Hope Project: genetic profiling of 2500 patients with genetic disorders to determine the distribution of mutations in different Iran provinces Phase 1: attracted 700,000 $ 1000 patients with inborn errors of metabolism and hereditary eye disorders  
2017-present Collaborative Project: Hope Generation Foundation Iran RP Society Genetic Profiling of Iranian patients with inherited retinal disorders using targeted next generation sequencing of 316 known genes associated with hereditary eye disorders  
2017-present Collaborative Project: Hope Generation Foundation Iran Hemophilia Center A comprehensive genetic approach to 100 Iranian patients with Glanzmann thrombasthenia by mutation analysis of known related genes using targeted next generation sequencing  
2017-present Hope Generation Foundation   Clinical Application of Next Generation Sequencing in Personalized Medicine: Simultaneous Investigation of Somatic Point Mutations, Copy Number Variations and Cytogenetic Rearrangements (fusion proteins) using Oncomine Comprehensive Cancer Panel  
2015-present Hope Generation Foundation Avicenna Research Institute Determining the Distribution of Genetic Causes among Iranian Patients with Premature Ovarian Insufficiency using a Comprehensive Algorithm with a Specific Approach to Single Gene Disorders by Whole Exome Sequencing  
2016-present Collaborative Project: Hope Generation Foundation Vali E-Asr Rehabilitation Foundation   Determining the Genetic Causes of Familial Cerebral Palsy using Whole Exome Sequencing Attracted 30,000$  
2015-present Hope Generation Foundation   Assessment of Single Gene Disorders in Familial Intellectual Disability by Whole Exome Sequencing
2017-present Hope Generation Foundation   Development, Optimization and validation of Copy Number Variation Analysis using Whole Exome Sequencing Data (Exome-Array)
2016-2017 Hope Generation Foundation Avicenna Research Institute Development and Optimization of Preimplantation High Resolution HLA Typing (8-digit) using Next Generation Sequencing (PGD-HLA-NGS)  
2015-2016 Hope Generation Foundation Avicenna Research Institute   Development and Optimization of PGS-NGS: Preimplantation Genetic Screening of All Chromosomal Aneuploidies using Next Generation Sequencing (Single Cell Whole Genome Amplification Followed by Low-Pass NGS Aneuploidy Detection)
2015-2016 Hope Generation Foundation Iranian Blood Transfusion Organization   Development and Optimization of HLA Typing using Next Generation Sequencing
2015 Hope Generation Foundation Design the Specific Gene Sets for Targeted Next Generation Sequencing in Heterogenous Disorders (Intellectual Disability, Hearing Impairment, Retinitis Pigmentosa, Neuromuscular Disorders, Genodermatoses, …)
2015 Optimization and Clinical Application of Next GenerationSequencing Technique Hope Generation Foundation  
2013-2015 Avicenna Infertility Clinic, Avicenna Research Institute Construction of Repeat-Free Fluorescence In Situ Hybridization Probes (High-Definition DNA FISH)
2012-2015 Avicenna Infertility Clinic, Avicenna Research Institute   Optimization and Clinical Application of Preimplantation Genetic Diagnosis (PGD) in a Wide Range of Single Gene Disorders
2012-2013 Avicenna Infertility Clinic, Avicenna Research Institute Optimization of Single Cell Whole Genome Amplification Technique
2012-2015 Gene Clinic Iranian RP Society Mutation Analysis of RP2 Gene in X-linked Retinitis Pigmentosa patients
2012-2014 Hope Generation Foundation Iranian RP Society   Mutation Analysis of RHO Gene in Autosomal Dominant Retinitis Pigmentosa patients
2010-2013 Comprehensive Genetic Center, Faculty of Medicine, Tehran University of Medical Sciences Iranian RP Society A Comprehensive Genomic Approach to Autosomal Recessive Retinitis Pigmentosa using Next Generation Sequencing Technique
2011-present Hope Generation Foundation   Investigation of the Pregnancy Outcome of More than 22000 Women Referred for First/Second Trimester Screening and/or ultrasound study
2012-present Hope Generation Foundation   Investigation of the Clinical Significance of Prenatally Detected Ultrasound Abnormalities by Active Follow up of the Pregnancies with Affected Fetuses
2010- Present Hope Generation Foundation Design and Implementation of Integrated Data Mining and Analysis of More than 101000 Pregnant Women Referred for First/SecondTrimester Screening and/or ultrasound study
2010-2013 Hope Generation Foundation Investigation of Aneuploidies and Cryptic Chromosomal Abnormalities in Products of Conception
2010-2011 Comprehensive Genetic Center, Faculty of Medicine, Tehran University of Medical Sciences   Determining the Deletions and Duplications of F8 Gene in Severe Haemophilia A Patients with Inhibitor Development
2010-2011 Comprehensive Genetic Center, Faculty of Medicine, Tehran University of Medical Sciences Rapid Prenatal Diagnosis of Chromosomal Aneuploidies in Amniotic Fluid or Chorionic Villus Samples using MLPA Technique
2009-2011 Comprehensive Genetic Center, Faculty of Medicine, Tehran University of Medical Sciences Iranian RP Society   Determining the Distribution of Different Modes of Inheritance among Iranian Patients with Retinitis Pigmentosa by Pedigree Analysis of 3950 Iranian RP Families registered in Iranian RP Society
2009-2010 Comprehensive Genetic Center, Faculty of Medicine, Tehran University of Medical Sciences Investigation of Deletions and Duplications of F8 Gene in Iranian Severe Haemophilia A Patients Using MLPA Technique
2008-2011 Comprehensive Genetic Center, Faculty of Medicine, Tehran University of Medical Sciences Design A Comprehensive Stepwise Diagnostic Approach to Mental Retardation by Determining the Molecular Profile of DNA Copy Number Abnormalities,
2010-2012 Comprehensive Genetic Center, Faculty of Medicine, Tehran University of Medical Sciences Preimplantation Genetic Diagnosis of Spinal Muscular Atrophy
2010-2011 Comprehensive Genetic Center, Faculty of Medicine, Tehran University of Medical Sciences Investigation of Chromosomal Aneuploidies in Oral SCC Tumors
2009-2011, Gene Clinic Assessment of Her-2 Amplification Status in Iranian Breast Cancer Patients:  Comparison of IHC and FISH
2007-2009 Cancer research Center, Iranian Genetic core Facility Comparative Genomic Hybridization Analysis of Esophageal tumors, Tarbiat Modares University  
2006-2007 Reproductive health research center, Cancer research Center Determination of RBC Indices and Mutation Detection in Infants with the Haemoglobin Bart’s Hydrops Fetalis Syndrom and their parents  
2005-2006 Cancer research center, Reproductive Health Research Center Detection of HPV infection using molecular techniques in 134 families    
2005-2006 Cancer Institute, Central Children Hospital, Pasteur Institute, Genetic Office Determination of RBC Indices in the parents of Major Thalassemia Patients and Mutation Detection in Those Who Are Not Detectable by National Carrier Screening  programme,  
2003-2004 Gene Clinic, Children’s Central Hospital, Iranian Molecular Medicine, Department of Medical Genetics, Tehran Medical School, Cancer Research center   Application of FISH for the detection of chromosomal deletions in patients with congenital heart disease
2003-2004 Cancer Research Center   Early-detection of micrometastases in lymph nodes from patients with breast cancer by RT-PCR screening of axillary nodes, compared to routine histology.
2003-2004 Cancer Research Center Chromosomal aberrations detected by Comparative genomic hybridization (CGH) in invasive ductal carcinoma and peritumoral ductal carcinoma insitu (DCIS) and usual ductal hyperplasia.
2003-2004 Cancer Research Center Comparison of chromosomal aberration in two groups of invasive ductal carcinoma of breast with and without axillary lymph nodes metastasis by comparative genomic hybridization (CGH).  
2001-2003 Reproductive health research center, Reproductive Health Research Center, Assisted Reproductive Research Center, Gene Clinic Preimlantation genetic diagnosis using FISH technique, a Collaborative study
2001-2003 Gene ClinicChildren’s Central Hospital, Iranian Molecular Medicine Network, Cancer Research center Application of all (42) telomeric probes in the patients with idiopathic mental retardation
2001-2005 Gene Clinic, Reproductive Health Research Center, Iranian Molecular medicine network, Assisted reproductive research center, Cancer Research center Application of all (42) telomeric probes in the patients with recurrent abortions
2001-2002 Cancer Research center, Asthma and Immunology research center Radiation Induced Chromosomal Breakage Assay of Peripheral Lymphocytes in Patients with Familial and Sporadic Breast Cancer, a Comparative Study
2001-2002 Cancer Research Center, Asthma and Immunology Research Center   Chromosomal breakage study in the patients with Ataxia Telangectasia, a Comparative Study
 

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