Development of First Trimester Screening for Chromosomal Aneuploidies

 

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Authors
SR Ghaffari, AR Tahmasebpour, A Jamal, S Hantoushzadeh, L Eslamian, V Marsoosi, F Fattahi, M Rajaei, S Niroomanesh, S Borna, A Beigi, S Khazardoost, S Saleh‐Gargari, F Rahimi‐Sharbaf, B Farrokhi, N Bayani, SE Tehrani, K Shahsavan, S Farzan, S Moossavi, F Ramezanzadeh, J Dastan, M Rafati
Publication date
2012/5/1
Journal
Ultrasound in Obstetrics & Gynecology
Volume
39
Issue
5
Pages
528-534
Publisher
John Wiley & Sons, Ltd.
Description
Objective
To investigate the performance of first-trimester screening for chromosomal abnormalities by integrated application of nuchal translucency thickness (NT), nasal bone (NB), tricuspid regurgitation (TR) and ductus venosus (DV) flow combined with maternal serum free β-human chorionic gonadotropin (fβ-hCG) and pregnancy-associated plasma protein-A (PAPP-A) at a one-stop clinic for assessment of risk (OSCAR).
Methods
In total, 13 706 fetuses in 13 437 pregnancies were screened for chromosomal abnormalities during a period of 5 years. Maternal serum biochemical markers and maternal age were evaluated in combination with NT, NT+ NB, NT+ NB+ TR, and NT+ NB+ TR+ DV flow data in 8581, 242, 236 and 4647 fetuses, respectively.
Results
In total, 51 chromosomal abnormalities were identified in the study population, including 33 cases of trisomy 21, eight of trisomy 18, six of sex chromosome …

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